Comstock ___ (1850s discovery) NYT crossword answer is:
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The Comstock Lode was a major discovery in the 1850s in the United States, located in the Nevada Territory. It was the first major discovery of silver ore in the United States, and it led to a mining boom in the area. The Comstock Lode was a major factor in the development of the American West, and it is still remembered today as one of the most significant discoveries of the 19th century.