Lose ones shirt say NYT crossword answer is:
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The phrase "lose one's shirt" is a colloquialism that means to suffer a financial loss, usually a large one. It is often used in reference to stock market losses, where a person may be said to have "lost their shirt" if they have invested heavily and suffered a large financial loss. The phrase is also used to refer to any other type of financial loss, such as gambling losses or bad investments. The New York Times crossword clue for May 3, 2023, is likely referring to this phrase.